Mapping Cardiac Electromechanics in the Pig¶
Pig heart electromechanical data from the Shivkumar/Ardell group is displayed on a 3D pig heart scaffold. The deforming geometry of the pig heart is fitted through the cardiac cycle with the pig heart scaffold. Electrophysiological measurements from two 64-electrode patches, one on the left ventricle (LV) and one on the right ventricle (RV), are fitted as time-varying fields via scaffold parameters and shown on the LV and RV epicardial surfaces, respectively, of the beating heart model. Note that these electromechanical data, fitted to the 3D scaffold, are from the same pig heart and include both physiological normal contracting heart beats and the whole heart response to stellate stimulation. This use-case demonstrates the use of the scaffold to merge two types of data set (one mechanical and one electrophysiological) and begins to illustrate the connection between stimulation of the peripheral nervous system and the response at the whole heart level.
This document guides a user of the SPARC Data Portal through the steps required to discover some data looking at autonomic control of the heart.
Follow these step-by-step instructions to familiarise yourself with the flow of the web interface.
Step 1: The default Result column displays some of the use cases available on the portal. Click on the Mapping Cardiac Electromechanics in the Pig box.
Step 3: In the Scaffold Viewer tab, a 3D pig heart scaffold has been fitted to the 2D video data. In addition a 64-electrode patch mesh has been constructed from the original electrode patch on the surface of the left ventricular epicardium. Electro-physiological data recorded from this patch has been registered on the mesh and a field is displayed on the surface of this mesh. This mesh is then embedded on the corresponding surface of the scaffold.
Press play to see the video.
The following Figure depicts the workflow for the generation of the 3D scaffold.
In the current version, the scaffold has only been fitted to the video data through anisotropic scaling and some shear. This was a limitation as only one view angle was available. In future, a stereo camera system will be installed to reconstruct a 3D view of the beating heart in order to accurately fit the scaffold and capture the deformation of cardiac tissue.